Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223970 | 0.86 | CTSK (0.56) | CTSLCTSKABCB1ITGB3ITGA2B | |
| SCHEMBL30136171 | 0.84 | LMNA (0.50) | CTSLCTSKABCB1ACEITGB3 | |
| SCHEMBL7304574 | 0.84 | MAPT (0.52) | CTSLCTSKCCKBRACEKLK5 | |
| SCHEMBL8441060 | 0.83 | CTSL (0.55) | CTSLCTSK | |
| SCHEMBL7304605 | 0.83 | HTT (0.46) | CTSLCTSKITGB3ITGA2BKLK5 | |
| SCHEMBL22457264 | 0.81 | CTSL (0.61) | CTSLCTSKABCB1ITGB3ITGA2B | |
| SCHEMBL30645054 | 0.81 | CTSB (0.50) | CTSLCTSKCCKBRACEREN | |
| SCHEMBL7304175 | 0.81 | ITGB3 (0.43) | ABCB1CCKBRITGB3ITGA2B | |
| SCHEMBL16770322 | 0.80 | CTSL (0.56) | CTSLCTSKABCB1ITGB3ITGA2B | |
| SCHEMBL7305886 | 0.79 | CTSS (0.45) | CTSLCTSKABCB1CCKBRACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |