Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294910 | 0.92 | CTSK (0.53) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7427885 | 0.86 | CTSB (0.49) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7429221 | 0.86 | CTSK (0.52) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7434284 | 0.85 | CTSK (0.51) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7329100 | 0.85 | CTSK (0.51) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7427667 | 0.83 | REN (0.49) | CTSBCTSLCTSSCTSKREN | |
| SCHEMBL9724730 | 0.82 | TRPM8 (0.53) | CTSBCTSLCTSSCTSKALDH1A1 | |
| SCHEMBL8759915 | 0.82 | CTSB (0.55) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7278761 | 0.81 | REN (0.50) | CTSBCTSLCTSSCTSKREN | |
| SCHEMBL7293547 | 0.81 | CTSB (0.54) | CTSBCTSLCTSSCTSKCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368719-B1 | Novel analogs of peptidase substrates | MERRELL PHARMA INC (US) | 1997-01-08 | — | — | EP | disclosed |
| US-5114927-A | Hypotensive agents and inhibiting renin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0371179-A1 | Novel analogs of peptidase substrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0356595-A1 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-07 | — | — | EP | disclosed |