Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305975 | 0.88 | SIGMAR1 (0.54) | SIGMAR1KCNA3 | |
| SCHEMBL466989 | 0.87 | SIGMAR1 (0.57) | SIGMAR1HTR1A | |
| SCHEMBL7303423 | 0.83 | QDPR (0.51) | SIGMAR1CYP3A4HTR1A | |
| SCHEMBL7306525 | 0.82 | SIGMAR1 (0.61) | SIGMAR1HTR1A | |
| SCHEMBL7306014 | 0.81 | SIGMAR1 (0.58) | SIGMAR1KCNA3 | |
| SCHEMBL7300904 | 0.81 | HRH3 (0.61) | SIGMAR1 | |
| SCHEMBL7304603 | 0.81 | SIGMAR1 (0.45) | SIGMAR1KCNA3HTR1A | |
| SCHEMBL7296057 | 0.74 | SIGMAR1 (0.61) | SIGMAR1HTR1A | |
| SCHEMBL23805531 | 0.72 | SIGMAR1 (0.76) | SIGMAR1 | |
| SCHEMBL13166930 | 0.71 | HRH3 (0.74) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149817-A | Psychotropic agents | SHIONOGI & CO., LTD. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445701-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |