Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302178 | 0.89 | MMP1 (0.46) | KMT2AMEN1MMP1MMP14ALDH1A1 | |
| SCHEMBL7305973 | 0.85 | MEN1 (0.43) | KMT2AMEN1MMP1MMP14ALDH1A1 | |
| SCHEMBL7308927 | 0.77 | MMP1 (0.50) | MMP1MMP14ALDH1A1MMP2MMP3 | |
| SCHEMBL16111262 | 0.74 | LMNA (0.50) | KMT2AMEN1ALDH1A1NPC1MAPT | |
| SCHEMBL7313882 | 0.74 | MMP1 (0.55) | MMP1MMP14MMP2MMP3MMP9 | |
| SCHEMBL7303606 | 0.73 | MMP1 (0.43) | MMP1MMP14ALDH1A1MMP2MMP3 | |
| SCHEMBL2409029 | 0.73 | MMP1 (0.50) | MMP1MMP14ALDH1A1MMP2MMP3 | |
| SCHEMBL7304697 | 0.73 | MMP1 (0.54) | MMP1MMP14MMP2MMP3MMP9 | |
| SCHEMBL7304591 | 0.73 | MMP1 (0.64) | MMP1MMP14MMP2MMP3MMP9 | |
| SCHEMBL2324751 | 0.71 | OPRM1 (0.52) | ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |