Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687154 | 0.88 | GPR119 (0.35) | ADRB1PDE3BPDE3AADRB3ABCB11 | |
| SCHEMBL9687447 | 0.87 | MAPK1 (0.41) | ADRB1ADRB2HTR1AOPRK1PDE3B | |
| SCHEMBL7303996 | 0.86 | CTSS (0.43) | ADRB1ADRB2ADRB3GPR119 | |
| SCHEMBL7305054 | 0.84 | SLC22A1 (0.39) | ADRB1ADRB2HTR1APDE3BPDE3A | |
| SCHEMBL7304427 | 0.83 | ADRB2 (0.43) | ADRB1ADRB2HTR1AADRB3GPR119 | |
| SCHEMBL7304449 | 0.83 | PDE3B (0.39) | ADRB1ADRB2HTR1AOPRK1PDE3B | |
| SCHEMBL9687171 | 0.83 | PDE3B (0.41) | PDE3BPDE3AADRB3ABCB11MAOA | |
| SCHEMBL7300352 | 0.83 | ADRB1 (0.51) | ADRB1ADRB2HTR1AOPRK1PDE3B | |
| SCHEMBL7306614 | 0.82 | ADRB1 (0.52) | ADRB1ADRB2HTR1AOPRK1PDE3B | |
| SCHEMBL7304010 | 0.80 | PDE3B (0.43) | ADRB1ADRB2PDE3BPDE3AADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |