Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 6/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309594 | 0.91 | HTR7 (0.68) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7306583 | 0.85 | HTR1A (0.70) | HTR1ADRD2ADRA1AADRA1BHTR7 | |
| SCHEMBL7312723 | 0.81 | HTR1A (0.57) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7300518 | 0.79 | HTR7 (0.77) | HTR1ADRD2HTR7HTR2A | |
| SCHEMBL7300725 | 0.79 | HTR7 (0.67) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7298112 | 0.78 | MAOA (0.46) | KDM4E | |
| SCHEMBL8943310 | 0.78 | HTR7 (0.81) | HTR1ADRD2HTR7 | |
| SCHEMBL7303980 | 0.77 | PARP1 (0.60) | HTR1AKDM4E | |
| SCHEMBL8136027 | 0.76 | HTR7 (0.72) | HTR1AHTR7LMNA | |
| SCHEMBL7310111 | 0.76 | MAOA (0.46) | KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |