Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.46 |
| ▸ | FOS | P01100 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10776070 | 0.89 | LDHA (0.58) | ALOX15ALOX12LDHAMMP1CYP3A4 | |
| SCHEMBL7290411 | 0.89 | LDHA (0.58) | ALOX15ALOX12LDHAMMP1CYP3A4 | |
| SCHEMBL7298435 | 0.89 | LDHA (0.58) | ALOX15ALOX12LDHAMMP1CYP3A4 | |
| SCHEMBL13802900 | 0.81 | CA2 (0.50) | ALOX15ALOX12LDHACYP3A4FOS | |
| SCHEMBL11695436 | 0.80 | ALOX15 (0.66) | ALOX15ALOX12MMP1CYP3A4FOS | |
| SCHEMBL6344277 | 0.80 | CYP3A4 (0.71) | ALOX15ALOX12MMP1CYP3A4FOS | |
| SCHEMBL4432280 | 0.79 | MMP1 (0.53) | LDHAMMP1CYP3A4FOSTTR | |
| Hydrochloric Acid SCHEMBL11696571 | 0.79 | ALOX15 (0.64) | ALOX15ALOX12MMP1CYP3A4FOS | |
| SCHEMBL24497200 | 0.78 | LDHA (0.53) | ALOX15ALOX12LDHACYP3A4FOS | |
| SCHEMBL4748125 | 0.78 | STAT3 (0.51) | ALOX15ALOX12LDHACYP3A4CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490823-B1 | Dihydro-isoquinoline derivates | SANDOZ LTD (CH) | 1996-11-13 | — | — | EP | disclosed |
| US-5177085-A | DIHYDRO-ISOQUINOLINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN TREATING ASTHMA | SANDOZ LTD. (CH) | 1993-01-05 | — | — | US | disclosed |
| EP-0490823-A1 | Dihydro-isoquinoline derivates | SANDOZ LTD. (CH) | 1992-06-17 | — | — | EP | disclosed |