Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 2/20 | 0.41 |
| ▸ | ACR | P10323 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KLK1 | P06870 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648216 | 0.95 | KMT2A (0.47) | ACRMAPTKMT2APRSS1MEN1 | |
| SCHEMBL9231748 | 0.89 | ACR (0.40) | ACRMAPTKMT2APRSS1CA12 | |
| SCHEMBL9235998 | 0.89 | ACR (0.40) | ACRMAPTKMT2APRSS1CA12 | |
| SCHEMBL11305070 | 0.87 | PRSS1 (0.53) | ACRMAPTKMT2APRSS1CA12 | |
| SCHEMBL7306887 | 0.86 | PRSS1 (0.56) | ACRMAPTKMT2APRSS1CA12 | |
| SCHEMBL11284366 | 0.84 | KMT2A (0.53) | KMT2AMEN1ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL11277772 | 0.83 | MEN1 (0.55) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11277245 | 0.82 | MGLL (0.48) | ACRMAPTKMT2APRSS1MEN1 | |
| SCHEMBL11308016 | 0.81 | KMT2A (0.47) | ACRMAPTKMT2APRSS1CA12 | |
| SCHEMBL11432494 | 0.81 | KMT2A (0.50) | ACRMAPTKMT2APRSS1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4021472-A | ANTIPLASMIN AND ANTITRYPSIN | ONO PHARMACEUTICAL CO., LTD. (JA) | 1977-05-03 | — | — | US | disclosed |