Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | LGMN | Q99538 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302376 | 0.89 | MMP2 (0.50) | MMP2MMP13MMP1LIPELGMN | |
| SCHEMBL7299694 | 0.75 | MMP13 (0.62) | MMP2MMP13MMP1LGMNSMN1; SMN2 | |
| SCHEMBL7301657 | 0.74 | RXRB (0.39) | MMP2MMP13MMP1LIPESCN9A | |
| SCHEMBL27463208 | 0.72 | CNR1 (0.40) | MMP2MMP13MMP1LIPEHRH3 | |
| SCHEMBL940743 | 0.71 | PTGS2 (0.57) | LIPESCN9AP2RX3DAGLAHRH3 | |
| SCHEMBL20325535 | 0.71 | LIPE (0.48) | MMP2MMP13MMP1LIPESCN9A | |
| SCHEMBL8423711 | 0.70 | LIPE (0.47) | LIPESCN9AFPR2P2RX3DAGLA | |
| SCHEMBL10833967 | 0.69 | DAGLA (0.44) | MMP2MMP13MMP1LIPEP2RX3 | |
| SCHEMBL8626757 | 0.68 | OPRM1 (0.48) | LIPESCN9AFPR2P2RX3 | |
| SCHEMBL6808653 | 0.67 | PTGS2 (0.53) | LIPEP2RX3DAGLAHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |