Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 9/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306490 | 0.85 | RXRB (0.39) | RXRBGRIN2BP2RX3LIPEFAAH | |
| SCHEMBL7310773 | 0.83 | MMP1 (0.41) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL7307841 | 0.74 | MMP2 (0.43) | P2RX3LIPEDAGLAMMP1MMP2 | |
| SCHEMBL7302376 | 0.69 | MMP2 (0.50) | P2RX3LIPEDAGLAMMP1MMP2 | |
| SCHEMBL7303122 | 0.67 | ALDH1A1 (0.34) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL7307600 | 0.65 | MMP13 (0.46) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL7300208 | 0.65 | MMP13 (0.78) | MMP1ABCB11MMP2MMP3MMP7 | |
| SCHEMBL8426091 | 0.64 | MMP2 (0.47) | MMP1ABCB11MMP2MMP3MMP7 | |
| SCHEMBL940743 | 0.64 | PTGS2 (0.57) | P2RX3LIPEDAGLASCN9A | |
| SCHEMBL20325535 | 0.64 | LIPE (0.48) | LIPEDAGLAMMP1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |