Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.46 |
| ▸ | MMP2 | P08253 | 9/20 | 0.46 |
| ▸ | MMP13 | P45452 | 9/20 | 0.46 |
| ▸ | MMP3 | P08254 | 5/20 | 0.44 |
| ▸ | MMP7 | P09237 | 5/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310800 | 0.87 | MMP2 (0.46) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL7308960 | 0.80 | MMP13 (0.42) | MMP1MMP2MMP13MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL7309427 | 0.79 | MMP1 (0.53) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL7307600 | 0.78 | MMP13 (0.46) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL6796941 | 0.71 | MMP3 (0.56) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL7310773 | 0.69 | MMP1 (0.41) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL6789829 | 0.69 | MMP2 (0.54) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL12020262 | 0.68 | MMP2 (0.69) | MMP1MMP2MMP13MMP3MMP7 | |
| SCHEMBL7308959 | 0.66 | MMP13 (0.58) | MMP1MMP2MMP13 | |
| SCHEMBL7308976 | 0.66 | MMP13 (0.58) | MMP1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |