Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.42 |
| ▸ | MMP1 | P03956 | 7/20 | 0.42 |
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 6/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310800 | 0.80 | MMP2 (0.46) | MMP13MMP1MMP3MMP9MMP7 | |
| SCHEMBL7308050 | 0.80 | MMP1 (0.46) | MMP13MMP1MMP3MMP9MMP7 | |
| SCHEMBL7307600 | 0.72 | MMP13 (0.46) | MMP13MMP1MMP3MMP9MMP7 | |
| SCHEMBL7310773 | 0.69 | MMP1 (0.41) | MMP13MMP1MMP3MMP9MMP7 | |
| SCHEMBL6796941 | 0.65 | MMP3 (0.56) | MMP13MMP1MMP3MMP9MMP7 | |
| SCHEMBL7749707 | 0.64 | MMP13 (0.47) | MMP13MMP1MMP9ALDH1A1MMP2 | |
| SCHEMBL2226633 | 0.63 | MMP2 (0.52) | ALDH1A1KMT2AMMP2 | |
| SCHEMBL10153787 | 0.63 | VNN1 (0.51) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7749551 | 0.63 | MMP13 (0.46) | MMP13MMP1MMP9ALDH1A1MMP2 | |
| SCHEMBL6789829 | 0.63 | MMP2 (0.54) | MMP13MMP1MMP3MMP9MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |