Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 14/20 | 0.38 |
| ▸ | MMP9 | P14780 | 11/20 | 0.38 |
| ▸ | MMP14 | P50281 | 7/20 | 0.38 |
| ▸ | MMP13 | P45452 | 4/20 | 0.38 |
| ▸ | MMP8 | P22894 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301657 | 0.83 | RXRB (0.39) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7303122 | 0.83 | ALDH1A1 (0.34) | MMP1MMP3MMP7MMP2MMP9 | |
| Hydrochloric Acid SCHEMBL8425471 | 0.72 | MMP1 (0.48) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7307600 | 0.71 | MMP13 (0.46) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7310800 | 0.69 | MMP2 (0.46) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7308050 | 0.69 | MMP1 (0.46) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7308960 | 0.69 | MMP13 (0.42) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL20204133 | 0.67 | CNR2 (0.35) | MMP1MMP3MMP2MMP9MMP14 | |
| SCHEMBL8426091 | 0.62 | MMP2 (0.47) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL12717525 | 0.62 | MMP2 (0.74) | MMP1MMP3MMP7MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |