Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308833 | 0.96 | L3MBTL1 (0.58) | L3MBTL1RORCHTTHDAC8ALDH1A1 | |
| SCHEMBL8410410 | 0.92 | ALDH1A1 (0.60) | L3MBTL1RORCHTTALDH1A1MMP3 | |
| SCHEMBL3084650 | 0.85 | RORC (0.59) | L3MBTL1RORCHTTALDH1A1POLB | |
| SCHEMBL8407961 | 0.83 | MMP3 (0.47) | L3MBTL1RORCHDAC8MMP3HPGD | |
| SCHEMBL8410615 | 0.82 | KMT2A (0.47) | L3MBTL1RORCALDH1A1MMP3POLB | |
| SCHEMBL8886185 | 0.81 | RORC (0.53) | RORCALDH1A1POLB | |
| SCHEMBL878909 | 0.81 | KMT2A (0.53) | HTTALDH1A1POLBHPGD | |
| SCHEMBL8886444 | 0.80 | CNR1 (0.53) | HTTALDH1A1MMP3POLB | |
| SCHEMBL7473435 | 0.80 | POLB (0.53) | RORCHTTHDAC8ALDH1A1POLB | |
| SCHEMBL9223532 | 0.80 | POLB (0.64) | L3MBTL1RORCHTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |