Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 6/20 | 0.44 |
| ▸ | MMP13 | P45452 | 5/20 | 0.44 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311621 | 0.84 | ALDH1A1 (0.44) | ADAM17ALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL7300038 | 0.84 | LDHA (0.45) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7551513 | 0.81 | ADAM17 (0.52) | ADAM17ALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL6934693 | 0.79 | ALDH1A1 (0.60) | ADAM17ALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL6819804 | 0.79 | MMP3 (0.63) | ALDH1A1KMT2AMEN1MMP1MMP13 | |
| SCHEMBL6930628 | 0.77 | ADAM17 (0.64) | ADAM17ALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL27464871 | 0.76 | MMP13 (0.48) | ADAM17ALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL7307517 | 0.74 | ADAM17 (0.43) | ADAM17ALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL7646610 | 0.74 | ADAM17 (0.47) | ADAM17ALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL6930702 | 0.73 | MMP9 (0.68) | ADAM17ALDH1A1KMT2AMEN1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1177821-C | Matrix metalloprotease inhibitors | - | 2004-12-01 | — | — | CN | disclosed |
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| CN-1160045-A | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 1997-09-24 | — | — | CN | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |