Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.74 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | APEX1 | P27695 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308987 | 0.86 | ADRB2 (0.68) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL233810 | 0.85 | ADRB1 (1.00) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL20961 | 0.85 | ADRB1 (1.00) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL6510329 | 0.85 | ADRB1 (1.00) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL20960 | 0.85 | ADRB1 (1.00) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL16821829 | 0.84 | ADRB1 (0.98) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL4269272 | 0.84 | ADRB1 (0.98) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL3137123 | 0.84 | ADRB2 (0.98) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL3137111 | 0.84 | ADRB2 (0.98) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Bisoprolol SCHEMBL16821831 | 0.84 | ADRB1 (0.98) | ADRB2ADRB1ADRB3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4171370-A | Phenoxy-amino-propanols | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-10-16 | — | — | US | disclosed |