SCHEMBL731273

SCHEMBL731273

CCOC(=O)C(C)Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1

nearest known ligand 0.83

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.62
SMN1; SMN2 Q16637 4/20 0.60
LMNA P02545 4/20 0.60
FFAR1 O14842 1/20 0.56
ALDH1A1 P00352 3/20 0.56
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
LIPE Q05469 1/20 0.53
MAPT P10636 2/20 0.51
POLB P06746 1/20 0.51
HTT P42858 1/20 0.51
PPARG P37231 1/20 0.50
RAB9A P51151 1/20 0.50
ATM Q13315 1/20 0.49
KDM4E B2RXH2 1/20 0.49
HPGD P15428 1/20 0.49
XBP1 P17861 1/20 0.49
TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10644305 0.92 SMN1; SMN2 (0.53) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL10644918 0.92 SMN1; SMN2 (0.53) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL164100 0.91 L3MBTL1 (0.77) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL29440928 0.91 L3MBTL1 (0.77) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL165715 0.91 L3MBTL1 (0.77) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL10688121 0.91 L3MBTL1 (0.62) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL9587608 0.90 SMN1; SMN2 (0.61) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL9414327 0.90 LMNA (0.60) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
SCHEMBL9366059 0.90 SMN1; SMN2 (0.58) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1
Haloxyfop-P-Methyl SCHEMBL54814 0.89 LMNA (0.65) L3MBTL1SMN1; SMN2LMNAFFAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9801374-B2 Active compound combinations comprising carboxamide derivatives BAYER CROPSCIENCE AG (DE) 2017-10-31 US disclosed
EP-1893016-B1 WATER-IN-OIL SUSPOEMULSIONS BAYER IP GMBH (DE) 2017-09-13 EP disclosed
US-9757407-B2 Treatment of viral infections by modulation of host cell metabolic pathways THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2017-09-12 US disclosed
EP-1651039-B1 OIL SUSPENSION CONCENTRATE CONTAINING DIFLUFENICAN BAYER IP GMBH (DE) 2017-01-04 EP disclosed
US-20160346309-A1 TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS UNIV PRINCETON (US) 2016-12-01 US disclosed
EP-1928232-B1 SOLID FORMULATION BAYER IP GMBH (DE) 2016-07-13 EP disclosed
US-20150245610-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2015-09-03 US disclosed
EP-2908639-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES Bayer Cropscience AG (DE) 2015-08-26 EP disclosed
US-9102623-B2 Pyridinecarboxamides, useful-plant-protecting composition comprising them and processes for their preparation and their use BAYER CROPSCIENCE AG (DE) 2015-08-11 US disclosed
US-20150139949-A1 ANTI-VIRAL COMBINATION THERAPY KOYUNCU EMRE (US) 2015-05-21 US disclosed
EP-0492366-A2 New 5-chloroquinolin-8-oxyalkanecarbonic acid derivatives, process for their preparation and their use as antidotes for herbicides Hoechst Schering AgrEvo GmbH (DE) 1992-07-01 EP disclosed
US-5082949-A Plant growth regulators, protective agents HOECHST AKTIENGESELLSCHAFT (DE) 1992-01-21 US disclosed
EP-0269806-B1 PHENYLPYRAZOLE CARBONIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS PLANT GROWTH REGULATORS AND ANTIDOTES HOECHST AKTIENGESELLSCHAFT (DE) 1991-02-27 EP disclosed
US-4976773-A SELECTIVITY BETWEEN MONOCOYLEDON PLANTS SUNTORY LIMITED (JP) 1990-12-11 US disclosed
US-4936892-A HERBICIDES; PLANT GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1990-06-26 US disclosed
US-4891057-A Phenylpyrazolecarboxylic acid derivatives, their preparation, and their use as plant-growth regulators and safeners HOECHST AKTIENGESELLSCHAFT (DE) 1990-01-02 US disclosed
EP-0303415-A2 Herbicidally active phenoxy-alkanecarboxylic acid derivatives SUNTORY LIMITED (JP) 1989-02-15 EP disclosed
US-4787930-A 5-amino-1-phenyl-pyrazole herbicides and plant growth regulators BAYER AKTIENGESELLSCHAFT (DE) 1988-11-29 US disclosed
US-4772312-A PRE-AND POSTEMERGENCE BAYER AKTIENGESELLSCHAFT (DE) 1988-09-20 US disclosed
WO-1988002598-A1 HERBICIDAL MIXTURES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150245610-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES AADAC, PFAS, CBR3 L3MBTL1 1739/4885SMN1; SMN2 4330/4885LMNA 4190/4885
US-20160346309-A1 TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS GOT2, MAVS, ME3 L3MBTL1 762/4885SMN1; SMN2 2585/4885LMNA 4191/4885
US-20150139949-A1 ANTI-VIRAL COMBINATION THERAPY HAVCR2, MAVS, ZC3HAV1 L3MBTL1 3171/4885SMN1; SMN2 4448/4885LMNA 4540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.