Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CFD | P00746 | 4/20 | 0.45 |
| ▸ | F11 | P03951 | 4/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318012 | 0.87 | NAAA (0.44) | L3MBTL1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7323366 | 0.82 | KMT2A (0.46) | MAPK1PTGER4PTGER2FOLH1MEN1 | |
| SCHEMBL19658180 | 0.81 | KMT2A (0.41) | MAPK1MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL12379257 | 0.81 | HTR1A (0.51) | HTR1ADRD2MAPK1PTGER1PTGER4 | |
| SCHEMBL5155762 | 0.81 | KMT2A (0.49) | L3MBTL1GAAMEN1MAPTKMT2A | |
| SCHEMBL2450503 | 0.80 | KMT2A (0.57) | MAPK1L3MBTL1ALDH1A1HPGDKMT2A | |
| SCHEMBL620077 | 0.79 | MAPK14 (0.41) | MAPK1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8324677 | 0.79 | L3MBTL1 (0.64) | HTR1ADRD2MAPK1CFDF11 | |
| SCHEMBL8613427 | 0.78 | POLB (0.41) | MAPK1L3MBTL1GAAALDH1A1LMNA | |
| SCHEMBL2988197 | 0.77 | L3MBTL1 (0.56) | HTR1ADRD2CFDF11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306912-B1 | POLYAMINO CARBONYLAMINO ALKYL FLUORO SUBSTITUTES INDOLE COMPOUNDS | NPS PHARMACEUTICALS, INC. | 2001-10-23 | — | — | US | disclosed |
| EP-1123922-A2 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases | NPS PHARMACEUTICALS, INC. (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6071970-A | FOR TREATING PATIENTS HAVING NEUROLOGICAL DISEASE OR DISORDER, SUCH AS STROKE, HEAD TRAUMA, SPINAL CORD INJURY, EPILEPSY, ANXIETY, OR NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, PARKINSON'S DISEASE | NPS PHARMACEUTICALS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-6051610-A | COMPOUNDS USEFUL AS NEUROPROTECTANTS, ANTICONVULSANTS, ANXIOLYTICS, ANALGESICS, MUSCLE RELAXANTS OR ADJUVANTS TO GENERAL ANESTHETICS | NPS PHARMACEUTICALS, INC. (US) | 2000-04-18 | — | — | US | disclosed |