Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323413 | 0.90 | TP53 (0.45) | TP53MAPTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL7325273 | 0.89 | MEN1 (0.49) | TP53MAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL7323166 | 0.86 | ALDH1A1 (0.44) | TP53ALDH1A1L3MBTL1LMNAHPGD | |
| SCHEMBL7317479 | 0.84 | TP53 (0.47) | TP53MAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL7317380 | 0.84 | TP53 (0.47) | TP53ALDH1A1L3MBTL1LMNAHPGD | |
| SCHEMBL7323299 | 0.81 | MEN1 (0.45) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7322403 | 0.80 | MTNR1A (0.46) | ALDH1A1MEN1KMT2ANPC1SLC16A3 | |
| SCHEMBL7316263 | 0.80 | MEN1 (0.67) | TP53ALDH1A1L3MBTL1LMNAHPGD | |
| SCHEMBL7313454 | 0.78 | ACLY (0.51) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL7321851 | 0.77 | METAP2 (0.58) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |