Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314715 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MAPK1SMN1; SMN2RECQLLMNA | |
| SCHEMBL4674228 | 0.84 | LMNA (0.59) | ALDH1A1SMN1; SMN2LMNAMGLLMMP1 | |
| SCHEMBL4674225 | 0.84 | LMNA (0.59) | ALDH1A1SMN1; SMN2LMNAMGLLMMP1 | |
| SCHEMBL8104005 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPK1SMN1; SMN2RECQLLMNA | |
| SCHEMBL7319451 | 0.78 | KMT2A (0.50) | SMN1; SMN2RECQLMMP3MMP1MMP2 | |
| SCHEMBL4672695 | 0.78 | KMT2A (0.50) | SMN1; SMN2RECQLMMP3MMP1MMP2 | |
| SCHEMBL8104008 | 0.76 | SMN1; SMN2 (0.47) | ALDH1A1MAPK1SMN1; SMN2RECQLLMNA | |
| SCHEMBL11614797 | 0.74 | ALDH1A1 (0.73) | ALDH1A1MAPK1SMN1; SMN2RECQLLMNA | |
| SCHEMBL4673322 | 0.72 | MMP1 (0.59) | SMN1; SMN2LMNAMMP1MMP2MMP13 | |
| SCHEMBL4673329 | 0.72 | MMP1 (0.59) | SMN1; SMN2LMNAMMP1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |