Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103946 | 0.84 | LMNA (0.58) | ALDH1A1SMN1; SMN2LMNAHTTMGLL | |
| SCHEMBL7314715 | 0.79 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2LMNAHTTMGLL | |
| SCHEMBL7314720 | 0.79 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2LMNAHTTMGLL | |
| SCHEMBL8096541 | 0.78 | FAAH (0.51) | GAA | |
| SCHEMBL8104008 | 0.77 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2LMNAHTTMGLL | |
| SCHEMBL8096415 | 0.73 | MMP12 (0.45) | LMNAMAPT | |
| SCHEMBL31279890 | 0.71 | ALDH1A1 (0.59) | ALDH1A1HTTMGLLKDM2BMAPK1 | |
| SCHEMBL19317518 | 0.71 | ALDH1A1 (0.59) | ALDH1A1HTTMGLLKDM2BMAPK1 | |
| SCHEMBL11614797 | 0.68 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2LMNAHTTMGLL | |
| SCHEMBL4670876 | 0.68 | LMNA (0.50) | ALDH1A1LMNAMGLLMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |