Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | CPA3 | P15088 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323948 | 0.84 | CPA3 (0.52) | CPA3FOLH1MME | |
| SCHEMBL7315467 | 0.84 | CPA3 (0.52) | CPA3FOLH1MME | |
| SCHEMBL7333784 | 0.84 | CPA3 (0.52) | CPA3FOLH1MME | |
| SCHEMBL7313773 | 0.84 | CPA3 (0.52) | CPA3FOLH1MME | |
| SCHEMBL7324292 | 0.81 | LIPC (0.35) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7315216 | 0.77 | ECE1 (0.49) | CAPN1CTSLCPA3 | |
| Hydrochloric Acid SCHEMBL7854941 | 0.76 | ECE1 (0.48) | CAPN1CTSL | |
| SCHEMBL7312449 | 0.76 | CPA3 (0.43) | CPA3FOLH1MME | |
| SCHEMBL7311722 | 0.76 | ALDH1A1 (0.36) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7315209 | 0.75 | PTGS2 (0.40) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | claimed |
| EP-0805817-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2001-08-16 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5866604-A | Thiol derivatives with metallopeptidase inhibitory activity | ZAMBON GROUP S.P.A. (IT) | 1999-02-02 | — | — | US | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |