Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317410 | 0.90 | ALDH1A1 (0.47) | PLA2G2AMAPTLMNAALDH1A1GAA | |
| SCHEMBL7316889 | 0.89 | MMP1 (0.41) | PLA2G2AMAPTLMNAALDH1A1GAA | |
| SCHEMBL7317152 | 0.88 | MMP1 (0.38) | PLA2G2AMAPTLMNAALDH1A1KMT2A | |
| SCHEMBL7322659 | 0.81 | MMP2 (0.47) | MAPTALDH1A1GAAMEN1POLB | |
| SCHEMBL7313804 | 0.81 | ALDH1A1 (0.45) | PLA2G2AMAPTLMNAALDH1A1GAA | |
| SCHEMBL7321207 | 0.81 | ALDH1A1 (0.45) | PLA2G2AMAPTLMNAALDH1A1GAA | |
| SCHEMBL7318307 | 0.81 | ALDH1A1 (0.45) | PLA2G2AMAPTLMNAALDH1A1GAA | |
| SCHEMBL7324368 | 0.81 | CA1 (0.42) | PLA2G2AMAPTLMNAALDH1A1PKM | |
| SCHEMBL7316532 | 0.80 | ALDH1A1 (0.44) | PLA2G2AMAPTLMNAALDH1A1GAA | |
| SCHEMBL7323399 | 0.80 | MMP9 (0.49) | MMP1MMP2MMP3MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |