Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | KIF11 | P52732 | 4/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315704 | 1.00 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1SLC6A4SLC6A3 | |
| SCHEMBL7323867 | 0.86 | KIF11 (0.44) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7317362 | 0.86 | KIF11 (0.44) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7317367 | 0.86 | KIF11 (0.44) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7324896 | 0.86 | ESR1 (0.43) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7324901 | 0.86 | ESR1 (0.43) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7316108 | 0.84 | KIF11 (0.45) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7316115 | 0.84 | KIF11 (0.45) | SLC1A3SLC1A2SLC1A1KIF11PDK2 | |
| SCHEMBL7322362 | 0.84 | ACHE (0.44) | KIF11CYP1A2CYP2C19HIF1AAKR1C3 | |
| SCHEMBL7322359 | 0.84 | ACHE (0.44) | KIF11CYP1A2CYP2C19HIF1AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |