Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.42 |
| ▸ | MMP1 | P03956 | 9/20 | 0.42 |
| ▸ | MMP3 | P08254 | 9/20 | 0.42 |
| ▸ | MMP9 | P14780 | 13/20 | 0.41 |
| ▸ | MMP13 | P45452 | 12/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 6/20 | 0.40 |
| ▸ | MMP12 | P39900 | 6/20 | 0.40 |
| ▸ | MMP14 | P50281 | 6/20 | 0.40 |
| ▸ | MMP16 | P51512 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324791 | 0.91 | MMP1 (0.39) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7322755 | 0.90 | MMP2 (0.40) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7322141 | 0.85 | MMP9 (0.45) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7324134 | 0.81 | MMP1 (0.40) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7318226 | 0.78 | MMP13 (0.53) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7321501 | 0.78 | MMP3 (0.50) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7312522 | 0.76 | MMP13 (0.46) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7311930 | 0.76 | MMP13 (0.48) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7323861 | 0.74 | MMP2 (0.41) | MMP2MMP1MMP3MMP9MMP13 | |
| SCHEMBL7317836 | 0.74 | PLA2G2A (0.39) | MMP2MMP1MMP3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |