Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.45 |
| ▸ | MMP2 | P08253 | 4/20 | 0.42 |
| ▸ | MMP8 | P22894 | 4/20 | 0.42 |
| ▸ | MMP12 | P39900 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP14 | P50281 | 4/20 | 0.42 |
| ▸ | MMP16 | P51512 | 4/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322659 | 0.92 | MMP2 (0.47) | TAS2R14MMP2MMP8MMP12MMP13 | |
| SCHEMBL7325574 | 0.91 | MMP2 (0.40) | TAS2R14MMP2MMP8MMP12MMP13 | |
| SCHEMBL7324368 | 0.91 | CA1 (0.42) | TAS2R14MMP2MMP8MMP12MMP13 | |
| SCHEMBL7321847 | 0.89 | MMP13 (0.44) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7311380 | 0.85 | NAMPT (0.48) | MMP2MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7317410 | 0.84 | ALDH1A1 (0.47) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7322414 | 0.83 | TP53 (0.45) | TAS2R14MMP2MMP8MMP12MMP13 | |
| SCHEMBL7322985 | 0.83 | MMP2 (0.45) | TAS2R14MMP2MMP8MMP12MMP13 | |
| SCHEMBL7317729 | 0.83 | RAPGEF4 (0.43) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7318675 | 0.83 | MMP2 (0.45) | TAS2R14MMP2MMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |