Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP14 | P50281 | 4/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP12 | P39900 | 3/20 | 0.39 |
| ▸ | MMP16 | P51512 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316684 | 0.93 | MMP9 (0.46) | MMP13ADAM17MMP1MMP9MMP2 | |
| SCHEMBL7319249 | 0.93 | MMP13 (0.43) | MMP13ADAM17MMP1MMP9MAPT | |
| SCHEMBL7323399 | 0.90 | MMP9 (0.49) | MMP13ADAM17MMP1MMP9TP53 | |
| SCHEMBL7313417 | 0.88 | CNR2 (0.39) | MMP13ADAM17MMP1MMP9MMP2 | |
| SCHEMBL7317152 | 0.86 | MMP1 (0.38) | MMP13ADAM17MMP1MMP9MAPT | |
| SCHEMBL7310752 | 0.86 | MMP9 (0.47) | MMP13ADAM17MMP1MMP9MMP2 | |
| SCHEMBL7315893 | 0.85 | MMP13 (0.47) | MMP13ADAM17MMP1MMP9GAA | |
| SCHEMBL7325559 | 0.83 | CA1 (0.47) | MMP13ADAM17MMP1MMP9MMP2 | |
| SCHEMBL7325505 | 0.83 | MMP9 (0.46) | MMP13ADAM17MMP1MMP9TP53 | |
| SCHEMBL7319004 | 0.82 | MMP9 (0.48) | MMP13ADAM17MMP1MMP9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |