Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.43 |
| ▸ | MMP9 | P14780 | 10/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317445 | 0.93 | MMP13 (0.45) | MMP13MMP9ADAM17NPC1MAPT | |
| SCHEMBL7316684 | 0.92 | MMP9 (0.46) | MMP13MMP9ADAM17ALDH1A1MMP1 | |
| SCHEMBL7315893 | 0.89 | MMP13 (0.47) | MMP13MMP9ADAM17LMNANPC1 | |
| SCHEMBL7323399 | 0.89 | MMP9 (0.49) | MMP13MMP9ADAM17MMP1CA1 | |
| SCHEMBL7324951 | 0.87 | CTRC (0.43) | MMP13MMP9ADAM17LMNANPC1 | |
| SCHEMBL7313417 | 0.86 | CNR2 (0.39) | MMP13MMP9ADAM17NPC1RAB9A | |
| SCHEMBL7317152 | 0.84 | MMP1 (0.38) | MMP13MMP9ADAM17LMNAALDH1A1 | |
| SCHEMBL7310752 | 0.84 | MMP9 (0.47) | MMP13MMP9ADAM17ALDH1A1MMP1 | |
| SCHEMBL7322589 | 0.84 | CYP2D6 (0.42) | MMP13MMP9ADAM17ALDH1A1NPC1 | |
| SCHEMBL7325559 | 0.81 | CA1 (0.47) | MMP13MMP9ADAM17ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |