SCHEMBL7317868

SCHEMBL7317868

O=C(O)c1ccc(OCC2CCCCC2)cc1OCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 4/20 0.57
PARP15 Q460N3 3/20 0.57
SGMS2 Q8NHU3 1/20 0.49
C5AR1 P21730 1/20 0.47
MCL1 Q07820 1/20 0.47
MEN1 O00255 1/20 0.47
ALDH1A1 P00352 1/20 0.47
KMT2A Q03164 1/20 0.47
FFAR1 O14842 2/20 0.47
PPARD Q03181 2/20 0.47
MAOB P27338 1/20 0.46
SIRT2 Q8IXJ6 1/20 0.46
MET P08581 1/20 0.45
FOLH1 Q04609 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7907804 0.95 PARP10 (0.54) PARP10PARP15SGMS2C5AR1MCL1
SCHEMBL7317871 0.88 SGMS2 (0.55) PARP10PARP15SGMS2MEN1ALDH1A1
SCHEMBL7911253 0.84 PARP10 (0.56) PARP10PARP15SGMS2C5AR1MEN1
SCHEMBL7322745 0.83 PARP10 (0.53) PARP10PARP15MAOBSIRT2
SCHEMBL4756552 0.83 MAOB (0.63) MCL1MEN1ALDH1A1KMT2AMAOB
SCHEMBL7316315 0.82 MET (0.55) SGMS2MET
SCHEMBL4653952 0.82 PARP10 (0.60) PARP10PARP15ALDH1A1FFAR1MAOB
SCHEMBL4654741 0.81 PARP10 (0.61) PARP10PARP15ALDH1A1FFAR1MAOB
SCHEMBL5968109 0.80 SGMS2 (0.55) SGMS2MEN1ALDH1A1KMT2AMAOB
SCHEMBL23436508 0.79 C5AR1 (0.49) C5AR1FFAR1PPARDMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927035-A4 THROMBIN INHIBITORS MERCK & CO INC (US) 2002-11-13 EP disclosed
EP-0927035-A1 THROMBIN INHIBITORS Merck & Co., Inc. (US) 1999-07-07 EP disclosed
US-5872138-A INHIBITING LOSS OF BLOOD PLATELETS, INHIBITING FORMATION OF BLOOD PLATELET AGGREGATES, INHIBITING FORMATION OF FIBRIN, INHIBITING THROMBUS FORMATION, AND INHIBITING EMBOLUS FORMATION IN A MAMMAL MERCK & CO., INC. (US) 1999-02-16 US disclosed
WO-1998010763-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 1998-03-19 WO disclosed