Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321024 | 0.90 | RAB9A (0.46) | NPC1RAB9AKMT2AALDH1A1HTT | |
| SCHEMBL7316351 | 0.90 | NPC1 (0.55) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL7318543 | 0.88 | SMN1; SMN2 (0.47) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL10584481 | 0.87 | NPC1 (0.38) | NPC1RAB9AKMT2AMEN1CCR1 | |
| SCHEMBL7318507 | 0.84 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7318668 | 0.84 | CNR2 (0.42) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL7275454 | 0.81 | CCR1 (0.45) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL7375088 | 0.81 | TDP1 (0.40) | KMT2AALDH1A1MEN1 | |
| SCHEMBL7322701 | 0.78 | METAP2 (0.40) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL7316425 | 0.76 | ALDH1A1 (0.44) | NPC1RAB9AKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280956-B1 | THIAZOLIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-10-21 | — | — | EP | claimed |
| US-4857537-A | PREVENTING AMNESIA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | claimed |
| EP-0280956-A1 | Thiazolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | claimed |