Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556385 | 0.82 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL7354500 | 0.79 | LMNA (0.60) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL7329311 | 0.75 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL3781692 | 0.75 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL7358861 | 0.71 | LMNA (0.60) | ALDH1A1SMN1; SMN2LMNAGAAMAPK1 | |
| SCHEMBL13995385 | 0.71 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL11146076 | 0.70 | LMNA (0.64) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL11997720 | 0.69 | L3MBTL1 (0.55) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL6755308 | 0.69 | ACACB (0.55) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12733161 | 0.69 | ACACB (0.55) | ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |