Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | CTSE | P14091 | 1/20 | 0.51 |
| ▸ | PGC | P20142 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323392 | 0.84 | MEN1 (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2REN | |
| SCHEMBL9556385 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL7319330 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL7354500 | 0.74 | LMNA (0.60) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL10375806 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL29392186 | 0.70 | GNPAT (0.59) | — | |
| SCHEMBL10618982 | 0.70 | ERAP2 (0.53) | — | |
| SCHEMBL17903209 | 0.68 | CA2 (0.50) | — | |
| SCHEMBL29613396 | 0.67 | NPY4R (0.61) | — | |
| SCHEMBL14063686 | 0.67 | SMN1; SMN2 (0.53) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |