Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354500 | 0.83 | LMNA (0.60) | ALDH1A1KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL7319330 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL7329311 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL7323392 | 0.80 | MEN1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9822661 | 0.75 | SLC7A5 (0.59) | — | |
| SCHEMBL2878352 | 0.75 | MME (0.66) | GAAMAPT | |
| SCHEMBL29498365 | 0.75 | MME (0.66) | GAAMAPT | |
| SCHEMBL4778524 | 0.75 | MME (0.66) | GAAMAPT | |
| SCHEMBL17903209 | 0.74 | CA2 (0.50) | — | |
| SCHEMBL30564982 | 0.73 | ENPEP (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |