Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319268 | 0.80 | HSD11B1 (0.46) | ALDH1A1HTTPKMNLRP3LMNA | |
| SCHEMBL4404105 | 0.75 | HTT (0.55) | ALDH1A1HTTMAPTHPGDCCR6 | |
| SCHEMBL7317875 | 0.73 | FAAH (0.36) | ALDH1A1HTTMAPTLMNAKMT2A | |
| SCHEMBL2095302 | 0.72 | PKM (0.69) | ALDH1A1HTTMAPTPKMNLRP3 | |
| SCHEMBL7320942 | 0.71 | ALDH1A1 (0.44) | ALDH1A1HTTMAPTCACNA1BAPBA1 | |
| SCHEMBL3100969 | 0.70 | ALDH1A1 (0.51) | ALDH1A1HTTMAPTPKMNLRP3 | |
| SCHEMBL4407904 | 0.70 | ALDH1A1 (0.68) | ALDH1A1HTTMAPTHPGDCCR6 | |
| SCHEMBL97009 | 0.70 | HTT (0.60) | ALDH1A1HTTMAPTHPGDCCR6 | |
| SCHEMBL156901 | 0.70 | HTT (0.60) | ALDH1A1HTTMAPTHPGDCCR6 | |
| SCHEMBL4675275 | 0.69 | HSD11B1 (0.64) | ALDH1A1HTTMAPTHPGDCCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | disclosed |