Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTRA2 | O43464 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11709937 | 0.86 | PDE4A (0.69) | PDE4AMEN1KMT2AMAPTKDM4E | |
| SCHEMBL7326155 | 0.79 | PDE4A (0.50) | PDE4AMAPTKDM4EPGRHTT | |
| SCHEMBL7320359 | 0.79 | CTSS (0.47) | PDE4AKDM4EPGR | |
| SCHEMBL14112775 | 0.75 | PDE4A (0.51) | PDE4ACACNA1GCACNA1BMEN1KMT2A | |
| SCHEMBL11777406 | 0.74 | NQO2 (0.49) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL1116276 | 0.73 | HTRA2 (0.56) | PDE4ACACNA1GCACNA1BMEN1KMT2A | |
| SCHEMBL12326172 | 0.73 | PTGS2 (0.53) | MEN1KMT2AGAAPTGS2ALDH1A1 | |
| SCHEMBL395933 | 0.73 | PGR (0.46) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL10555140 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL10465079 | 0.71 | PGR (0.42) | KDM4ELMNATP53PGRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |