Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | AR | P10275 | 8/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 5/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11709937 | 0.83 | PDE4A (0.69) | PDE4APGRKDM4E | |
| SCHEMBL7328419 | 0.79 | AR (0.43) | ARPGRKDM4E | |
| SCHEMBL7319956 | 0.79 | PDE4A (0.50) | PDE4APGRKDM4E | |
| SCHEMBL7326155 | 0.76 | PDE4A (0.50) | ARPDE4APGRKDM4E | |
| SCHEMBL7317023 | 0.76 | ALDH1A1 (0.48) | PDE4AS1PR1KDM4E | |
| SCHEMBL7283993 | 0.76 | KIF11 (0.58) | CTSSCTSKARPGRPIM1 | |
| SCHEMBL7317586 | 0.74 | AR (0.43) | ARPGR | |
| SCHEMBL10554573 | 0.73 | RXRA (0.42) | ARPGRKDM4E | |
| SCHEMBL7330415 | 0.73 | KDM4E (0.52) | PDE4AS1PR1KDM4E | |
| SCHEMBL7330422 | 0.73 | KDM4E (0.52) | PDE4AS1PR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |