Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.43 |
| ▸ | PGR | P06401 | 4/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320359 | 0.79 | CTSS (0.47) | ARPGRKDM4E | |
| SCHEMBL7317586 | 0.77 | AR (0.43) | ARPGRKIF11 | |
| SCHEMBL18832308 | 0.74 | KIF11 (0.52) | ARPGRNOTUMKDM4EKIF11 | |
| SCHEMBL24909337 | 0.74 | XDH (0.36) | ARPGRP4HBKIF11 | |
| SCHEMBL7325347 | 0.73 | AR (0.35) | ARPGRESR1ESR2KDM4E | |
| SCHEMBL7275576 | 0.73 | KIF11 (0.63) | ARPGRHSD17B1HSD17B2P4HB | |
| SCHEMBL1938893 | 0.73 | HSD17B1 (0.65) | ARPGRHSD17B1HSD17B2ESR1 | |
| SCHEMBL29485676 | 0.73 | HSD17B1 (0.65) | ARPGRHSD17B1HSD17B2ESR1 | |
| SCHEMBL395933 | 0.73 | PGR (0.46) | PGRESR1ESR2KDM4E | |
| SCHEMBL7319411 | 0.73 | GAA (0.50) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |