Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | TUBB4A known ✓ | P04350 | 1/20 | 0.38 |
| ▸ | TUBB known ✓ | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B known ✓ | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A known ✓ | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B known ✓ | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 known ✓ | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A known ✓ | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A known ✓ | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 1/20 | 0.38 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 1/20 | 0.38 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325116 | 0.95 | KMT2A (0.51) | KMT2AMAPTSMN1; SMN2ELANEMAPK1 | |
| SCHEMBL7325111 | 0.95 | KMT2A (0.51) | KMT2AMAPTSMN1; SMN2ELANEMAPK1 | |
| SCHEMBL7333102 | 0.84 | MAPT (0.48) | KMT2AMAPTELANEMAPK1KDM4E | |
| SCHEMBL7333700 | 0.83 | ELANE (0.41) | MAPTELANEMAPK1KDM4ELMNA | |
| SCHEMBL10851091 | 0.81 | FTO (0.52) | KMT2AMAPTMEN1LMNAFTO | |
| SCHEMBL7329818 | 0.80 | KMT2A (0.46) | KMT2AMAPTSMN1; SMN2ELANEMAPK1 | |
| SCHEMBL7341758 | 0.79 | FTO (0.56) | KMT2AMAPTKDM4ELMNAFTO | |
| SCHEMBL7324828 | 0.79 | FTO (0.47) | KMT2AMAPTLMNAFTOALDH1A1 | |
| SCHEMBL7330202 | 0.78 | TNFRSF1A (0.58) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL7320565 | 0.78 | MAPT (0.54) | MAPTELANEMAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4570006-A | ANTITHROMBIN; ENZYME AND HORMONE INHIBITORS | TORII & CO. LTD. (JP) | 1986-02-11 | — | — | US | disclosed |
| US-4514416-A | Amidine compound, process for producing same and anti-complement agent comprising same | TORII & CO. LTD. (JP) | 1985-04-30 | — | — | US | disclosed |