Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 11/20 | 0.38 |
| ▸ | MMP3 | P08254 | 8/20 | 0.38 |
| ▸ | MMP13 | P45452 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555901 | 0.88 | CTSK (0.46) | CTSSCTSKMMP2MMP3MMP1 | |
| SCHEMBL5709603 | 0.87 | CTSS (0.39) | CTSSCTSKMMP2MMP3MMP13 | |
| SCHEMBL5709644 | 0.87 | CTSS (0.35) | CTSSCTSKMMP2MMP3MMP1 | |
| SCHEMBL5709634 | 0.85 | MMP2 (0.38) | CTSSCTSKMMP2MMP3MMP13 | |
| SCHEMBL5709641 | 0.80 | LTB4R (0.41) | — | |
| SCHEMBL5709581 | 0.79 | CTSS (0.35) | CTSSCTSKMMP2MMP3MMP1 | |
| SCHEMBL9556339 | 0.79 | ENPEP (0.41) | CTSSCTSKMMP1FCER2 | |
| SCHEMBL7322599 | 0.78 | MMP1 (0.39) | MMP2MMP3MMP13MMP1MMP12 | |
| SCHEMBL5709642 | 0.77 | MMP1 (0.38) | CTSSCTSKMMP2MMP3MMP13 | |
| SCHEMBL6349082 | 0.76 | KDM4E (0.39) | MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229420-A | Renin inhibitor | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | claimed |
| WO-1990000051-A1 | ETHEREAL N-TERMINAL AMINODIOL AMINO ACID DERIVATIVES AS ANTI-HYPERTENSIVE AGENTS | G.D. SEARLE & CO. (US) | 1990-01-11 | — | — | WO | claimed |
| EP-0349921-A2 | Etheral n-terminal aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | claimed |