Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 7/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | PLAT | P00750 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500293 | 0.88 | LMNA (0.50) | F10PRSS1PRSS2PRSS3HSP90AA1 | |
| SCHEMBL7330212 | 0.81 | PRSS1 (0.49) | F10PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL7332581 | 0.78 | MEN1 (0.56) | F10PRSS1HSP90AA1HSP90AB1PLAU | |
| Trifluoroacetic Acid SCHEMBL13269478 | 0.78 | KLK1 (0.50) | F10HSP90AA1HSP90AB1PLAUF2 | |
| SCHEMBL7332926 | 0.78 | ALDH1A1 (0.49) | F10PLAUF2PLATPLG | |
| SCHEMBL7329834 | 0.75 | PRSS1 (0.56) | F10PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL7323564 | 0.74 | F2 (0.46) | F10PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL7323111 | 0.74 | F10 (0.48) | F10PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL29568370 | 0.73 | F12 (0.77) | PRSS1PLAUF2PLATPLG | |
| SCHEMBL29934139 | 0.73 | F12 (0.77) | PRSS1PLAUF2PLATPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4570006-A | ANTITHROMBIN; ENZYME AND HORMONE INHIBITORS | TORII & CO. LTD. (JP) | 1986-02-11 | — | — | US | disclosed |
| US-4514416-A | Amidine compound, process for producing same and anti-complement agent comprising same | TORII & CO. LTD. (JP) | 1985-04-30 | — | — | US | disclosed |