Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP16 | P51512 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319427 | 0.90 | RAPGEF4 (0.44) | TP53LMNARAPGEF4MEN1KMT2A | |
| SCHEMBL7317823 | 0.81 | ALDH1A1 (0.39) | TP53LMNARAPGEF4MEN1KMT2A | |
| SCHEMBL7317781 | 0.81 | RAPGEF4 (0.47) | TP53LMNARAPGEF4MEN1KMT2A | |
| SCHEMBL7311192 | 0.78 | HTT (0.43) | TP53LMNARAPGEF4PKMALDH1A1 | |
| SCHEMBL7323004 | 0.78 | RAPGEF4 (0.48) | TP53LMNARAPGEF4MEN1KMT2A | |
| SCHEMBL7318168 | 0.77 | MMP1 (0.42) | MEN1KMT2AALDH1A1MMP9MMP13 | |
| SCHEMBL7323700 | 0.77 | RAPGEF4 (0.48) | TP53LMNARAPGEF4MEN1KMT2A | |
| SCHEMBL7323686 | 0.77 | ALDH1A1 (0.46) | TP53LMNAMEN1KMT2APKM | |
| SCHEMBL7313804 | 0.76 | ALDH1A1 (0.45) | TP53LMNAMEN1KMT2APKM | |
| SCHEMBL7322418 | 0.76 | THRB (0.42) | TP53LMNARAPGEF4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |