Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP8 | P22894 | 6/20 | 0.44 |
| ▸ | MMP12 | P39900 | 6/20 | 0.44 |
| ▸ | MMP13 | P45452 | 6/20 | 0.44 |
| ▸ | MMP14 | P50281 | 6/20 | 0.44 |
| ▸ | MMP16 | P51512 | 6/20 | 0.44 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317781 | 0.88 | RAPGEF4 (0.47) | RAPGEF4PKMGAATP53LMNA | |
| SCHEMBL7317729 | 0.86 | RAPGEF4 (0.43) | RAPGEF4PKMGAATP53LMNA | |
| SCHEMBL7318226 | 0.86 | MMP13 (0.53) | RAPGEF4PKMGAATP53LMNA | |
| SCHEMBL7311552 | 0.84 | RAPGEF4 (0.41) | RAPGEF4PKMGAATP53LMNA | |
| SCHEMBL7322659 | 0.82 | MMP2 (0.47) | GAATP53MMP2MMP8MMP12 | |
| SCHEMBL7323861 | 0.81 | MMP2 (0.41) | RAPGEF4PKMGAATP53LMNA | |
| SCHEMBL7323589 | 0.81 | PTGS2 (0.41) | RAPGEF4PKMGAATP53LMNA | |
| Biphenyl SCHEMBL7320212 | 0.81 | MMP2 (0.45) | RAPGEF4GAATP53MMP2MMP8 | |
| SCHEMBL7316126 | 0.79 | TAS2R14 (0.45) | RAPGEF4GAATP53LMNAMMP2 | |
| SCHEMBL7315652 | 0.79 | MMP2 (0.49) | GAATP53MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |