Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 5/20 | 0.39 |
| ▸ | MMP12 | P39900 | 5/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 4/20 | 0.38 |
| ▸ | MMP13 | P45452 | 4/20 | 0.38 |
| ▸ | MMP14 | P50281 | 4/20 | 0.38 |
| ▸ | MMP16 | P51512 | 4/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323918 | 0.78 | TP53 (0.42) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7324085 | 0.78 | HTT (0.43) | HTTNPSR1MEP1BMMP2MMP12 | |
| SCHEMBL7323700 | 0.76 | RAPGEF4 (0.48) | HTTNPSR1MMP2MMP12MMP9 | |
| SCHEMBL7317823 | 0.76 | ALDH1A1 (0.39) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7319427 | 0.74 | RAPGEF4 (0.44) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7318675 | 0.74 | MMP2 (0.45) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7311552 | 0.74 | RAPGEF4 (0.41) | HTTNPSR1MMP2MMP12MMP9 | |
| SCHEMBL7323861 | 0.74 | MMP2 (0.41) | MMP2MMP12MMP9MMP8MMP13 | |
| SCHEMBL7317729 | 0.73 | RAPGEF4 (0.43) | HTTNPSR1MMP2MMP12MMP9 | |
| SCHEMBL7323152 | 0.72 | EGFR (0.43) | NPSR1MMP2MMP12MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |