Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315592 | 0.91 | METAP2 (0.46) | METAP2ALDH1A1HPGDHSD17B10SLC16A3 | |
| SCHEMBL7322650 | 0.85 | METAP2 (0.58) | METAP2ALDH1A1HPGDHSD17B10FFAR4 | |
| SCHEMBL7325546 | 0.84 | METAP2 (0.56) | METAP2ALDH1A1HPGDHSD17B10FABP4 | |
| SCHEMBL7324937 | 0.82 | METAP2 (0.54) | METAP2ALDH1A1HPGDHSD17B10FABP4 | |
| SCHEMBL7317403 | 0.78 | METAP2 (0.48) | METAP2ALDH1A1FFAR4MEN1KMT2A | |
| SCHEMBL7325564 | 0.77 | METAP2 (0.49) | METAP2ALDH1A1HPGDHSD17B10ACLY | |
| SCHEMBL7318667 | 0.76 | METAP2 (0.45) | METAP2ALDH1A1MEN1KMT2APKM | |
| SCHEMBL7313454 | 0.74 | ACLY (0.51) | METAP2ALDH1A1HPGDHSD17B10SLC16A3 | |
| SCHEMBL7316128 | 0.74 | MEN1 (0.48) | METAP2SLC16A3FABP4MEN1KMT2A | |
| SCHEMBL7315641 | 0.74 | METAP2 (0.54) | METAP2ALDH1A1HPGDHSD17B10FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |