Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554573 | 0.79 | RXRA (0.42) | ARPGRKDM1ARXRARXRG | |
| SCHEMBL7319411 | 0.79 | GAA (0.50) | RXRAKDM4EALDH1A1SLC9A1CYP1A2 | |
| SCHEMBL18832308 | 0.78 | KIF11 (0.52) | ARPGRKIF11KDM4EALDH1A1 | |
| SCHEMBL8999890 | 0.71 | KIF11 (0.46) | KDM1ARXRARXRGKIF11 | |
| Hydrochloric Acid SCHEMBL7320013 | 0.70 | SLC9A1 (0.45) | KDM1AKDM4EALDH1A1SLC9A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7320004 | 0.70 | CYP1A2 (0.39) | KDM1AKDM4EALDH1A1SLC9A1CYP1A2 | |
| SCHEMBL395933 | 0.69 | PGR (0.46) | PGRKDM4EALDH1A1ESR1ESR2 | |
| SCHEMBL29320291 | 0.68 | RXRA (0.55) | ARRXRARXRGKIF11CYP1A2 | |
| Cyanate SCHEMBL30681205 | 0.67 | CES2 (0.43) | ARKIF11 | |
| SCHEMBL1409490 | 0.67 | HIF1A (0.39) | KIF11KDM4EALDH1A1SLC9A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |