SCHEMBL7325399

SCHEMBL7325399

COc1ccc(S(=O)(=O)Nc2c(C)ccc(C)c2C(=O)OCc2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 3/20 0.54
TP53 P04637 6/20 0.52
ALDH1A1 P00352 4/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
LMNA P02545 1/20 0.52
HPGD P15428 1/20 0.52
HTT P42858 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
CYTH2 Q99418 1/20 0.51
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
KEAP1 Q14145 1/20 0.49
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
LIMK2 P53671 1/20 0.47
POLB P06746 1/20 0.47
MAPT P10636 4/20 0.47
GABRG2 P18507 1/20 0.47
GABRB3 P28472 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7323413 0.85 TP53 (0.45) TP53ALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL7323418 0.77 MMP9 (0.61) ALDH1A1LMNAKEAP1NPSR1MAPT
SCHEMBL7314690 0.74 MMP13 (0.74) ALDH1A1LMNAMEN1KMT2AKEAP1
SCHEMBL7314686 0.74 TP53 (0.48) TP53ALDH1A1L3MBTL1LMNAHPGD
SCHEMBL7323166 0.72 ALDH1A1 (0.44) FFAR4TP53ALDH1A1L3MBTL1LMNA
SCHEMBL6961262 0.72 ALDH1A1 (0.53) TP53ALDH1A1L3MBTL1LMNAHPGD
SCHEMBL7322403 0.72 MTNR1A (0.46) FFAR4ALDH1A1MEN1KMT2ATSHR
SCHEMBL6390804 0.71 ADAMTS4 (0.64) ALDH1A1POLB
SCHEMBL6390801 0.71 ADAMTS4 (0.64) ALDH1A1POLB
SCHEMBL5159892 0.71 FFAR4 (0.74) FFAR4TP53ALDH1A1L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed