Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 6/20 | 0.32 |
| ▸ | CCR1 | P32246 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334672 | 0.85 | MTNR1A (0.41) | HPGDSMN1; SMN2 | |
| SCHEMBL7326609 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL9730335 | 0.78 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7329638 | 0.70 | KDM4E (0.57) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6334232 | 0.66 | KDM4E (0.44) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3965154 | 0.66 | KDM4E (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3966675 | 0.66 | KDM4E (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7318822 | 0.65 | KDM4E (0.44) | KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7274096 | 0.65 | MEN1 (0.37) | KDM4E | |
| SCHEMBL9789206 | 0.64 | MCL1 (0.35) | KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102901-A | 5-hydroxytrypamine receptor antaonists | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-04-07 | — | — | US | disclosed |
| EP-0393766-A2 | New 3-N substituted carbamoyl-indole derivatives | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-10-24 | — | — | EP | disclosed |