Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CES2 | O00748 | 2/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483965 | 0.86 | LMNA (0.53) | LMNACES2CES1MAPK1MEN1 | |
| SCHEMBL1395462 | 0.84 | LMNA (0.52) | LMNACES2CES1MAPK1MEN1 | |
| SCHEMBL2053138 | 0.84 | LMNA (0.52) | LMNACES2CES1MAPK1MEN1 | |
| SCHEMBL754132 | 0.81 | CYP2C19 (0.58) | LMNACES2CES1MAPK1MEN1 | |
| SCHEMBL11667579 | 0.80 | LMNA (0.47) | LMNACES2CES1MAPK1MEN1 | |
| SCHEMBL4769362 | 0.80 | LMNA (0.47) | LMNACES2CES1MAPK1KDM4E | |
| SCHEMBL4348607 | 0.79 | CES2 (0.59) | LMNACES2CES1MAPK1KDM4E | |
| Formic Acid SCHEMBL28872029 | 0.79 | LMNA (0.46) | LMNACES2CES1MAPK1MEN1 | |
| SCHEMBL5928515 | 0.79 | ALDH1A1 (0.62) | LMNACES2CES1MEN1KMT2A | |
| SCHEMBL5843726 | 0.79 | MDM4 (0.53) | LMNACES2CES1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516980-B1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMA INC (US) | 1996-04-17 | — | — | EP | disclosed |