Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 6/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351879 | 0.81 | LTA4H (0.47) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL6486232 | 0.78 | METAP2 (0.39) | RENMETAP2METAP1CTSLCTSK | |
| SCHEMBL7359588 | 0.78 | METAP2 (0.39) | RENMETAP2METAP1CTSKCTSS | |
| SCHEMBL6561648 | 0.78 | CPB2 (0.38) | RENMETAP2METAP1CTSKCTSS | |
| SCHEMBL27822264 | 0.78 | METAP2 (0.38) | RENMETAP2METAP1CTSKCTSS | |
| SCHEMBL10767496 | 0.77 | REN (0.42) | RENMETAP2METAP1CTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL7327225 | 0.77 | METAP2 (0.50) | RENMETAP2METAP1CTSKCTSS | |
| SCHEMBL9819691 | 0.75 | METAP2 (0.38) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL9819688 | 0.75 | METAP2 (0.38) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL8175196 | 0.74 | METAP2 (0.55) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5095119-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-10 | — | — | US | disclosed |
| US-5075451-A | Pyrrolimidazolones useful as renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5064965-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-12 | — | — | US | disclosed |
| US-5023338-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |