Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 12/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351879 | 0.86 | LTA4H (0.47) | METAP2METAP1CPB2CTSSCTSK | |
| SCHEMBL6561648 | 0.81 | CPB2 (0.38) | METAP2METAP1CPB2GRNSORT1 | |
| SCHEMBL6486232 | 0.80 | METAP2 (0.39) | METAP2METAP1CPB2CTSSCTSK | |
| SCHEMBL7357763 | 0.79 | METAP2 (0.53) | METAP2METAP1CPB2GRNSORT1 | |
| SCHEMBL7327231 | 0.78 | REN (0.39) | METAP2METAP1CTSSCTSKSLC1A3 | |
| SCHEMBL27822264 | 0.77 | METAP2 (0.38) | METAP2METAP1CPB2CTSSCTSK | |
| SCHEMBL7350002 | 0.76 | METAP2 (0.48) | METAP2METAP1CPB2MMEACE | |
| SCHEMBL29387045 | 0.72 | GRN (0.52) | CPB2GRNSORT1LTA4HMME | |
| SCHEMBL9146938 | 0.71 | LTA4H (0.50) | CPB2GRNSORT1LTA4HMME | |
| SCHEMBL9146946 | 0.71 | LTA4H (0.50) | CPB2GRNSORT1LTA4HMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |